Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddingsArticle Published on 2023-12-012022-11-15 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] 치료제, [키워드] antiviral properties binding affinity cells Cheminformatics Compound compounds conducted coronavirus dataset dose-dependent inhibition drug design Drug discovery evaluate half-maximal inhibitory concentration in silico inhibitor inhibitory effect ligand-based drug design M pro Machine learning. machine-learning molecular protease Protease inhibitor screened selected thought Toxicity Virtual screening virus infectivity [DOI] 10.1080/14756366.2022.2132486 PMC 바로가기
Antibody Profiling in COVID-19 Patients with Different Severities by Using Spike Variant Protein Microarrays스파이크 변이 단백질 마이크로어레이를 사용한 다양한 중증도의 COVID-19 환자에서 항체 프로파일링Article Published on 2022-05-032022-09-11 Journal: Analytical Chemistry [Category] MERS, 변종, 진단, [키워드] ACE2 ACE2 binding antibody antibody isotypes collected competition COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical critical cases death demonstrated Disease progression dose-dependent inhibition Drug screening elevated evaluated except for healthy subject healthy subjects humoral Humoral immunity immune inhibitors Microarray Mild Neutralizing activity Neutralizing antibodies nonstructural protein 3 patients Perindopril Profiling Protein protein 3 ramipril serum serum IgG severity Specificities specificity spike spike variant spike variants variant [DOI] 10.1021/acs.analchem.1c05567 PMC 바로가기 [Article Type] Article
A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targetsShort Reports Published on 2021-12-282022-10-28 Journal: PLoS Biology [Category] COVID-19, SARS, [키워드] approved approved drugs autophagy cell cultures cell line clinically Compound conducted conserved coronavirus coronavirus 2 Coronavirus replication coronavirus target CoV CoV replication CoVs demonstrated dependent on dose-dependent inhibition effective effective therapy epithelial Factor FKBP8 Genes genome-wide CRISPR screen HCoV-229E Health highlighting highly pathogenic Host Huh7 human coronavirus identify independent Infection inhibitor MERS-CoV Middle East MINAR1 nasal over pathway Protein Replication required respiratory SARS-CoV SARS-COV-2 infection Support survival target therapeutic intervention Tmem41b Treatment virus replication viruses [DOI] 10.1371/journal.pbio.3001490 PMC 바로가기 [Article Type] Short Reports
Anti-SARS-CoV-2 Activity of Extracellular Vesicle Inhibitors: Screening, Validation, and Combination with RemdesivirArticle Published on 2021-09-162022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] activity anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral drug biogenesis calpeptin calu-3 cells clinical study Combination coronavirus disease COVID-19 cysteine cytotoxicity demonstrated dose-dependent inhibition drug Effect EVs exhibited expression extracellular vesicle Extracellular vesicles half-maximal inhibitory concentration Health IC50 Impact infected cell inhibited inhibitor inhibitors monotherapy pandemic pathway proteinase release mechanism Remdesivir SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 viral replication screened Screening significantly small molecule inhibitor therapeutic efficacy validation Vero E6 cell VERO-E6 virion virus [DOI] 10.3390/biomedicines9091230 PMC 바로가기 [Article Type] Article
A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agentsArticle Published on 2021-08-012022-10-27 Journal: Antiviral Research [Category] COVID-19, [키워드] added Air-liquid interface airway epithelial cell Antiviral antiviral agent antivirals apical side approved AT-511 AT-527 basolateral side Cell clinical development clinical testing collected Culture D614G dose-dependent inhibition drug EIDD-1931 GS-441524 human epithelial cell IFN in vitro infectious virus titer inhibit inhibitor medium molnupiravir parent nucleoside Primary human airway epithelial cells Protein Remdesivir replicate robust SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 replication selected shown tracheal Treatment viral replication Viral RNA virus were infected [DOI] 10.1016/j.antiviral.2021.105122 PMC 바로가기 [Article Type] Article
A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agentsArticle Published on 2021-08-012022-10-27 Journal: Antiviral Research [Category] Coronavirus, COVID-19, SARS, [키워드] added Air-liquid interface airway epithelial cell Antiviral antiviral agent antivirals apical side approved AT-511 AT-527 basolateral side Cell clinical development clinical testing collected Culture D614G dose-dependent inhibition drug EIDD-1931 GS-441524 human epithelial cell IFN in vitro infectious virus titer inhibit inhibitor medium molnupiravir parent nucleoside Primary human airway epithelial cells Protein Remdesivir replicate robust SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 replication selected shown tracheal Treatment viral replication Viral RNA virus were infected [DOI] 10.1016/j.antiviral.2021.105122 PMC 바로가기 [Article Type] Article
A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents항 바이러스제를 평가하기 위해 공기 액체 계면에서 1 차 인간 상피 세포에서 강력한 SARS-COV-2 복제 모델Article Published on 2021-08-012022-09-10 Journal: Antiviral Research [Category] 신약개발, 치료제, [키워드] added Air-liquid interface airway epithelial cell Antiviral antiviral agent antivirals apical side approved AT-511 AT-527 basolateral side Cell clinical development clinical testing collected Culture culture medium D614G dose-dependent inhibition drug EIDD-1931 epithelial cells GS-441524 human epithelial cell IFN in vitro infectious virus titer infectious virus titers inhibit inhibitor medium molnupiravir nucleoside parent nucleoside primary cell Primary human airway epithelial cells Protein Remdesivir remdesivir) replicate robust SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 replication selected shown tracheal Treatment Viral viral replication Viral RNA virus virus titers were infected [DOI] 10.1016/j.antiviral.2021.105122 PMC 바로가기 [Article Type] Article
Inhibitory Effect of Ophthalmic Solutions against SARS-CoV-2: A Preventive Action to Block the Viral Transmission?Article Published on 2021-07-212022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Action antiviral activity antiviral drug block Contact contaminated surface COVID-19 demonstrated dose-dependent inhibition droplets Effect evaluated experiment expression level eye drop global pandemic Health care worker highlighting hospital indicated infections molecular assays occur ocular Ocular surface ocular transmission ophthalmic ophthalmic solutions pathogen reduce responsible Result risk of infection SARS-CoV-2 solution source of infection Spread tested Transmission viral replication virus [DOI] 10.3390/microorganisms9081550 PMC 바로가기 [Article Type] Article
Antiviral Effect of Budesonide against SARS-CoV-2SARS-COV-2에 대한 Budesonide의 항 바이러스 효과Communication Published on 2021-07-202022-09-10 Journal: Viruses [Category] SARS, 변종, 치료제, [키워드] (alpha (Beta) administration alleviate Alpha antiviral activity antiviral drug antiviral drugs antivirals B.1.1.7 B.1.351 Budesonide caused Cell cell viability circulating variant comparable contribute coronavirus coronavirus 2 Corticosteroids COVID-19 COVID-19 symptom COVID-19 symptoms disease dose-dependent inhibition Effect glucocorticoid Glucocorticoids Infection Mild previous study recovery times reduce reduced reported respiratory respiratory viruses SARS-CoV-2 SARS-CoV-2 replication tested treatment for COVID-19 variants of concern viability Viral viral variant VoC [DOI] 10.3390/v13071411 PMC 바로가기 [Article Type] Communication
L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 InfectionArticle Published on 2021-04-142022-10-04 Journal: Nutrients [Category] MERS, SARS, 신약개발, [키워드] ACE-2 ACE2 ACE2 mRNA acute respiratory syndrome angiotensin-converting enzyme 2 Calu-3 cleavage coronavirus COVID-19 dose-dependent inhibition drug epithelial cells evaluated exercise expression levels Factors furin Host Human human lung Infection Inflammation L-carnitine limit Pandemics priming protease responsible rodent S-protein SARS-CoV-2 SARS-COV-2 infection serine 2 significant decrease Tartrate tested TMPRSS2 transmembrane Treatment treatment strategy Trial Vaccines viral spike [DOI] 10.3390/nu13041297 PMC 바로가기 [Article Type] Article